How antidepressants affect the cerebral ischemic injury and ischemic stroke

Ischemic stroke is the main cause of long-term disability and death worldwide. Studies have pointed out that antidepressants not only can be used to treat depression, but also promote nerve regeneration, plasticity, recovery function after stroke. Some evidences indicated beneficial effects on ischemic At same time, there are risks in treatment process. The mechanisms complicated rarely reported. This review summarizes roles patients animal models stroke, possible against brain injury induced by challenges with ischemia.